In eosinophilic esophagitis, a positive endoscopic biopsy confirms eosinophilic infiltration and supports which type of treatment?

• A. Confirms eosinophilic infiltration; supports dietary/anti-inflammatory treatment; monitor response with repeat endoscopy
• B. Diagnoses cancer
• C. Measures reflux
• D. Cures EoE

Answer: (A)

A positive biopsy showing eosinophilic infiltration confirms eosinophilic esophagitis and points to a management approach that targets reducing esophageal inflammation and removing triggers. The mainstay of treatment is dietary modification to identify and avoid offending foods plus anti-inflammatory therapy, typically with topical corticosteroids, to lessen eosinophilic inflammation. Because EoE is a chronic condition that can recur, clinicians monitor progress with repeat endoscopy and biopsies to verify histologic remission and mucosal healing.

Cancer diagnosis is not the purpose of this biopsy, and measuring reflux is not what this histology directly guides. While treatment can control symptoms and inflammation, EoE is not universally cured; ongoing management and follow-up are common.