Which of the following is a GI disorder differential for regurgitation associated with acid reflux?

• A. Megaesophagus
• B. Esophagitis
• C. Gastroesophageal Reflux Disease
• D. Cricopharyngeal Achalasia

Answer: (C)

Regurgitation with acid reflux points to a problem at the gastroesophageal junction where stomach contents flow back into the esophagus. The GI disorder that directly fits this pattern is gastroesophageal reflux disease, defined by reflux of gastric contents causing symptoms or mucosal damage. That makes it the best choice because it inherently involves acid reflux and regurgitation.

Megaesophagus can cause regurgitation due to a dilated, poorly motile esophagus, but this is a motor-issue mechanism rather than a primary acid-reflux process. Esophagitis is inflammation from reflux and can accompany GERD, but the underlying condition driving the reflux is GERD itself. Cricopharyngeal achalasia involves the upper esophageal sphincter and regurgitation from a pharyngeal–esophageal source rather than acid reflux into the esophagus.